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Peptides frequently have unstable structures. To create SP9, the group made use of a way termed hydrocarbon stapling to freeze it in a very form that blocks Syt2 from interacting Using the cell membrane proteins.
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Future, the crew analyzed SP9 With all the provider in living mice by spraying it immediately into your animals’ lungs. Imaging showed that all over a few-quarters of epithelial cells took up the peptide.
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